Construction began in 1534, but was not completed until 1626. Inside, the passage of time is evident in the architectural styles that have shaped it: Gothic, Plateresque, Renaissance, and Baroque. The church suffered significant damage during the Peninsular War, primarily affecting the roof and ornamentation.

Francisco de Goya painted a canvas to decorate the church, "The Assumption of the Virgin," located in the center of the High Altar in 1812, at the request of his brother Camilo, the church's chaplain.
